Lundi 25 juin 2018
Ecole Doctorale BIOLOGIE SANTE (ED n°446)
Faculté de Médecine Pôle Recherche
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59045 Lille cedex - France
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Séminaire : “STIM2-STIM1 interactions in regulation of Orai1 – Tuning the sensitivity of store-operated Ca2+ entry.”

21/06/2017 11:19 Il y a: 1 an(s)
Catégorie(s) : Manifestation scientifique

 

Mardi 27 juin 2017 – 10h

Bâtiment SN3, Salle Pasteur, Univ. Lille 1

INDU AMBUDKAR,

Secretory Physiology Section, Molecular Physiology and Therapeutics Branch, NIDCR, NIH, Bethesda US

Invitée par Prof. Natalia Prevarskaya, Laboratory of Cell Physiology INSERM U 1003 Université de Lille 1,

Dr Ambudkar is chief of the Secretory Physiology Section and chief of the Molecular Physiology and Therapeutics Branch in NIDCR NIH Bethesda, US.

She is one of the main specialist in the study of the role of Ca2+ signals and Transient Receptor Potential Channels in several axpects of cell physiology with particular interest in salivary gland fluid secretion. In her scientific career che uncovered the role of some key componets components that mediate and regulate Ca2+ entry into salivary gland cells and characterize the role of these in normal physiology as well as dysfunction/disease of salivary glands. Most of her studies have been directed directed towards identifying the function, regulation, trafficking and assembly of the transient receptor potential channel, TRPC1.

She have provided evidence that TRPC1 is an essential component of the agonist-stimulated Ca2+ influx mechanism that is required for sustained saliva secretion. She identified two other important components of this mechanism, the calcium channel, Orai1, and the ER regulator of calcium channels, STIM1. Current studies are directed to understand and define the individual contributions of TRPC1 and Orai1 to salivary fluid secretion. Moreover interested in identifying the regulation of the water channel, AQP5, during stimulation of the gland and secretion. Her work has led to the identification of TRPV4 as an essential TRP channel that is involved in cellular volume regulation. In addition other TRPC channels, TRPC3 and TRPC6, could also have important role in regulating other aspects of salivary gland function.

 

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